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A Biomimetic Approach to Lanthionines

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journal contribution
posted on 2012-01-06, 00:00 authored by Carlos Aydillo, Alberto Avenoza, Jesús H. Busto, Gonzalo Jiménez-Osés, Jesús M. Peregrina, María M. Zurbano
The asymmetric sulfa-Michael additions of appropriately protected l- and d-cysteine derivatives to new chiral dehydroamino acid derivatives have been developed as key steps in the synthesis of biologically important cysteine derivatives, such as lanthionine (Lan) and β-methyllanthionine (MeLan), which are unusual bis-α-amino acids found in the emerging lantibiotics such as nisin.

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