American Chemical Society
ol203068s_si_001.pdf (2.04 MB)

A Biomimetic Approach to Lanthionines

Download (2.04 MB)
journal contribution
posted on 2012-01-06, 00:00 authored by Carlos Aydillo, Alberto Avenoza, Jesús H. Busto, Gonzalo Jiménez-Osés, Jesús M. Peregrina, María M. Zurbano
The asymmetric sulfa-Michael additions of appropriately protected l- and d-cysteine derivatives to new chiral dehydroamino acid derivatives have been developed as key steps in the synthesis of biologically important cysteine derivatives, such as lanthionine (Lan) and β-methyllanthionine (MeLan), which are unusual bis-α-amino acids found in the emerging lantibiotics such as nisin.