posted on 2021-08-03, 15:09authored byAndrew
C. Jones, William I. Nicholson, Jamie A. Leitch, Duncan L. Browne
The nickel-catalyzed cross-electrophile
coupling of aryl halides
and alkyl halides enabled by ball-milling is herein described. Under
a mechanochemical manifold, the reductive C–C bond formation
was achieved in the absence of bulk solvent and air/moisture sensitive
setups, in reaction times of 2 h. The mechanical action provided by
ball milling permits the use of a range of zinc sources to turnover
the nickel catalytic cycle, enabling the synthesis of 28 cross-electrophile
coupled products.