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5-Alkylresorcinols from Merulius incarnatus

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journal contribution
posted on 28.04.2006, 00:00 by Wentao Jin, Jordan K. Zjawiony
Two new, 5-heptadeca-8‘Z,11‘Z,16-trienylresorcinol (1) and 5-heptadeca-9‘E,11‘Z,16-trienylresorcinol (2), and six known 5-alkylresorcinols (38) were isolated from the mushroom Merulius incarnatus. Compound 2 is the first 5-alkylresorcinol derivative that contains a transcis conjugated double bond system. Compounds 1, 2, 5, 6, 7, and 8 were found to inhibit methacillin-resistant Staphylococcus aureus (MRSA) with IC50 values of 2.5, 15, 9.5, 8.0, 5.0, and 6.5 μg/mL, respectively. Compound 1 was also active against leishmania, with an IC50 value of 3.6 μg/mL, and showed no cytotoxicity in our Vero cell test up to a concentration of 25 μg/mL. The structures of these isolates were determined by spectroscopic data including 1D and 2D NMR.