3-Benzyl-3-azabicyclo[3.1.1]heptan-6-one: A Promising Building Block for Medicinal Chemistry

Denisenko, Aleksandr V.; Mityuk, Andrey P.; Grygorenko, Oleksandr O.; Volochnyuk, Dmytro M.; Shishkin, Oleg V.; Tolmachev, Andrey A.; Mykhailiuk, Pavel K.

doi:10.1021/ol101866x.s001

ol101866x_si_001.pdf (11.27 MB)

3-Benzyl-3-azabicyclo[3.1.1]heptan-6-one: A Promising Building Block for Medicinal Chemistry

journal contribution

posted on 2010-10-01, 00:00 authored by Aleksandr V. Denisenko, Andrey P. Mityuk, Oleksandr O. Grygorenko, Dmytro M. Volochnyuk, Oleg V. Shishkin, Andrey A. Tolmachev, Pavel K. Mykhailiuk

An efficient two-step multigram synthesis of the previously unknown 3-benzyl-3-azabicyclo[3.1.1]heptan-6-one is described. The compound is shown to be a promising building block for further selective derivatization of the cyclobutane ring providing novel conformationally restricted piperidine derivatives.