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3,3‘-Br2-BINOL-Zn Complex:  A Highly Efficient Catalyst for the Enantioselective Hetero-Diels−Alder Reaction

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journal contribution
posted on 08.11.2002, 00:00 by Haifeng Du, Jiang Long, Jieyu Hu, Xin Li, Kuiling Ding
A BINOLate-zinc complex prepared in situ from Et2Zn and 3,3‘-dibromo-1,1‘-bi-2-naphthol (3,3‘-Br2-BINOL) was found to be a highly efficient catalyst for the enantioselective hetero-Diels−Alder reaction of Danishefsky's diene and aldehydes to give 2-substituted 2,3-dihydro-4H-pyran-4-one in up to quantitative yield and 98% ee.