posted on 2024-02-01, 06:13authored byChenhao Cong, Siva Subramanian, Gajanan A. Bodkhe, Guangwei Wang, Zhijun Li, Rixuan Wang, Xinlin Li, Myunghee Kim, Se Hyun Kim
The
rising prevalence of diabetes has led to an increased focus
on real-time glucose monitoring. Wearable glucose sensor patches allow
noninvasive, real-time monitoring, reducing patient discomfort compared
to invasive sensors. However, most existing glucose sensor patches
rely on complex and contaminating metal vapor deposition technologies,
which pose limitations in practical production. In this study, we
propose a novel approach for preparing graphite/multiwall carbon nanotubes
(MWCNT)/reduced graphene oxide (rGO) using a high-viscosity ink, which
can be easily obtained through simple mechanical stirring. To create
intricate patterns and enable printing on curved substrates, we employed
a 3D printer equipped with an infrared laser ranging system. The ink
served as a working electrode, and we developed a three-electrode
system patch with a concentric circle structure. Subsequently, the
working electrode underwent enzymatic modification with glucose dehydrogenase
with flavin adenine dinucleotide (GDH-FAD) using a polymer embedding
method. The resulting wearable glucose sensor exhibited a sensitivity
of 2.42 μA mM–1 and a linear detection range
of 1–12 mM. In addition, the glucose sensor has excellent anti-interference
capability and demonstrates good repeatability in simulated real human
wear scenarios, which meets the requirements for accurate human detection.
These findings provide valuable insights into the development of human
health monitoring technologies.