t‑BuOK-Mediated Oxidative Dehydrogenative C(sp3)‑H Arylation of 2‑Alkylazaarenes with Nitroarenes
journal contributionposted on 24.07.2017 by Shuai-Shuai Li, Shiheng Fu, Liang Wang, Lubin Xu, Jian Xiao
Any type of content formally published in an academic journal, usually following a peer-review process.
The first transition-metal free and regioselective C(sp3)-H arylation of 2-alkylazaarenes with nitroarenes has been achieved via t-BuOK-mediated dehydrogenative C(sp3)-C(sp2) coupling. This reaction provides an efficient access to the biologically important and synthetically useful 2-benzyl-substituted azaarenes under mild conditions without the need of prefunctionalization of 2-alkylazaarenes or using the specialized arylating agents.