Zn(II)-Catalyzed Synthesis of Piperidines from Propargyl Amines and Cyclopropanes
journal contributionposted on 20.08.2009 by Terry P. Lebold, Andrew B. Leduc, Michael A. Kerr
Any type of content formally published in an academic journal, usually following a peer-review process.
The reaction of benzyl-protected propargyl amines and 1,1-cyclopropane diesters in the presence of catalytic Zn(NTf2)2 allows access to highly functionalized piperidines in excellent yields. The process proceeds via a tandem cyclopropane ring-opening/Conia−ene cyclization.