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Zirconium(IV) Compounds As Efficient Catalysts for Synthesis of α-Aminophosphonates

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journal contribution
posted on 01.08.2008 by Srikant Bhagat, Asit K. Chakraborti
Zirconium(IV) compounds are reported as excellent catalysts for a three-component one-pot reaction of an amine, an aldehyde or a ketone, and a di/trialkyl/aryl phosphite to form α-aminophosphonates under solvent-free conditions at rt. Among the various zirconium compounds, ZrOCl2·8H2O and ZrO(ClO4)2·6H2O were most effective. The reactions were faster with dialkyl/diaryl phosphites than with trialkyl/triaryl phosphites. No O−Me cleavage occurs with aryl methyl ether and methyl ester groups. α,β-Unsaturated carbonyl moiety does not undergo conjugate addition with the phorphorous moiety.

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