Zinc-Mediated Allylation and Alkylation of Aminals in the Presence of TMSCl and Diisopropylamine
journal contributionposted on 21.11.2008 by Bunpei Hatano, Keita Nagahashi, Tatsuro Kijima
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An alkylation of aminals with organozinc reagents derived from allyl bromide, benzyl bromide, α-bromoacetate, and α-bromonitrile proceeded efficiently in the presence of TMSCl and diisopropylamine. This reaction system was applied to the synthesis of an antispasmodic: butaverine.