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Use of Acid Fluorides Increases the Scope of the Reductive Acylation of Esters

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journal contribution
posted on 27.05.2004 by Yongda Zhang, Tomislav Rovis
The use of acyl fluorides in the Rychnovsky reductive acylation of esters allows a variety of esters to be converted to their corresponding α-acyloxy ethers in good to excellent yields, without the need to sacrifice an extra equiv of carboxylic acid functionality.