Unprotected Vinyl Aziridines: Facile Synthesis and Cascade Transformations
journal contributionposted on 15.01.2010 by Sivaraj Baktharaman, Nicholas Afagh, Adelle Vandersteen, Andrei K. Yudin
Any type of content formally published in an academic journal, usually following a peer-review process.
Functionalized vinylaziridines, readily available from water-stable aziridine aldehydes have led to the construction of a variety of stereochemically rich heterobicycles. A cascade ring-opening/ring-contraction mechanism operates in the course of the process. These results underscore the notion that interesting and useful nitrogen-mediated relay processes can arise when elements of strain are merged with the manifolds of enamine/iminium ion reactivity.