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Two-Component Approach Toward a Fully Substituted N-Fused Pyrrole Ring

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journal contribution
posted on 16.07.2010 by Dmitri Chernyak, Cathy Skontos, Vladimir Gevorgyan
An efficient two-component palladium-catalyzed arylation/cyclization cascade approach toward a variety of N-fused pyrroloheterocycles has been developed. This transformation proceeds via the palladium-catalyzed coupling of aryl halides with propargylic esters or ethers followed by the 5-endo-dig cyclization leading to highly functionalized pyrroloheterocycles in good to excellent yield.