ol0342913_si_001.pdf (53.75 kB)

Trimethylsilyl Halide-Promoted Michaelis-Arbuzov Rearrangement

Download (53.75 kB)
journal contribution
posted on 23.04.2003, 00:00 by Pierre-Yves Renard, Philippe Vayron, Charles Mioskowski
We describe a new, straightforward, and easy-to-handle method for achieving an unprecedented trimethylsilyl halide-catalyzed Michaelis−Arbuzov-like rearrangement. This rearrangement occurs at temperatures from room temperature to 80 °C and does not require addition of any alkyl halide. The scope and limitations of this new reaction are explored, as well as its mechanism.