Total Synthesis of the Cytotoxic Anhydrophytosphingosine Pachastrissamine (Jaspine B)
journal contributionposted on 16.08.2013 by Vijay Dhand, Stanley Chang, Robert Britton
Any type of content formally published in an academic journal, usually following a peer-review process.
A short, 8-step synthesis of the marine natural product pachastrissamine has been developed that relies on a diastereoselective aldol reaction between a suitably protected hydantoin and an optically enriched α-chloroaldehyde. This synthetic route provides new opportunities for exploring structure activity relationships within this family of natural products.