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Total Synthesis of (−)‑N‑Methylwelwitindolinone B Isothiocyanate via a Chlorinative Oxabicycle Ring-Opening Strategy

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journal contribution
posted on 17.12.2015, 05:23 by Nicholas A. Weires, Evan D. Styduhar, Emma L. Baker, Neil K. Garg
The first total synthesis of N-methylwelwitindolinone B isothiocyanate is reported. The route features several key steps, including a regio- and diastereoselective chlorinative oxabicycle ring-opening reaction to introduce the challenging alkyl chloride motif.

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