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Total Synthesis of (−)-Okilactomycin

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journal contribution
posted on 05.12.2007 by Amos B. Smith, Kallol Basu, Todd Bosanac
A highly convergent synthesis of (−)-okilactomycin is described. Key reactions of this synthesis include a strategy-level diastereoselective oxy-Cope rearrangement/oxidation sequence, a Petasis−Ferrier union/rearrangement tactic, and an efficient RCM reaction to construct the 13-membered macrocyclic ring.