Total Synthesis of Integrastatin B Enabled by a Benzofuran Oxidative Dearomatization Cascade
journal contributionposted on 07.03.2016 by Atul A. More, Chepuri V. Ramana
Any type of content formally published in an academic journal, usually following a peer-review process.
The first total synthesis of integrastatin B, a potent HIV-1 integrase inhibitor, has been accomplished in seven steps with a 17.9% overall yield employing easily accessible starting compounds. The Oxone-mediated oxidative benzofuran dearomatization cascade has been employed as the key skeletal construct to forge the central tetracyclic nucleus.