Total Synthesis of Crambescidin 359
journal contributionposted on 29.12.2001 by Kazuo Nagasawa, Angelina Georgieva, Hiroyuki Koshino, Tadashi Nakata, Tetsuya Kita, Yuichi Hashimoto
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Crambescidin 359 (4), which is the “vessel part” of the pentacyclic guanidine alkaloid ptilomycalin A (1), was synthesized for the first time based upon successive 1,3-dipolar cycloaddition reaction. This synthesis established the absolute stereochemistry of 4.