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Total Synthesis of Crambescidin 359

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journal contribution
posted on 29.12.2001 by Kazuo Nagasawa, Angelina Georgieva, Hiroyuki Koshino, Tadashi Nakata, Tetsuya Kita, Yuichi Hashimoto
Crambescidin 359 (4), which is the “vessel part” of the pentacyclic guanidine alkaloid ptilomycalin A (1), was synthesized for the first time based upon successive 1,3-dipolar cycloaddition reaction. This synthesis established the absolute stereochemistry of 4.