Titanium Alkoxide-Based Regioselective Alkyne–Alkyne Reductive Coupling Mediated by In Situ Generated Arylamidate
journal contributionposted on 17.02.2020 by Bin Cai, James S. Panek
Any type of content formally published in an academic journal, usually following a peer-review process.
Titanium alkoxide-based alkyne–alkyne reductive coupling mediated by in situ generated arylamidate is described. A high level of regioselectivity is achieved in 37 examples, where (E,E)-dienes are exclusively formed. To the best of our knowledge, this study represents the first example of an apparent amide and carbamate directing effect in metal-mediated reductive coupling.