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Three New Scalarane Sesterterpenoids from the Okinawan Sponge Hyrtios erectus

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journal contribution
posted on 31.08.2000 by Hiroaki Miyaoka, Satoshi Nishijima, Hidemichi Mitome, Yasuji Yamada
Three new scalarane sesterterpenoidshyrtiolide (1), 16-hydroxyscalarolide (2), and 12-deacetyl-Δ17-hyrtial (3), were isolated from Okinawan sponge Hyrtios erectus, along with scalarolide (4) and 12-deacetylhyrtial (5). The structures of new compounds 13 were determined by spectroscopic analysis and chemical conversions. Compounds 3 and 5 showed antiproliferative activity toward KB cells.