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The Impact of Conformational Fluctuations on Self-Assembly: Cooperative Aggregation of Archaeal Chaperonin Proteins

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journal contribution
posted on 14.01.2009, 00:00 by Stephen Whitelam, Carl Rogers, Andrea Pasqua, Chad Paavola, Jonathan Trent, Phillip L. Geissler
Protein complexes called rosettasomes self-assemble in solution to form large-scale filamentous and planar structures. The relative abundance of these aggregates varies abruptly with environmental conditions and sample composition. Our simulations of a model of patchy nanoparticles can reproduce this sharp crossover, but only if particles are allowed to switch between two internal states favoring different geometries of local binding. These results demonstrate how local conformational adaptivity can fundamentally influence the cooperativity of pattern-forming dynamics.