## Ten-Input Cube Root Logic Computation with Rational Designed DNA Nanoswitches Coupled with DNA Strand Displacement Process

journal contribution

posted on 03.01.2020, 19:11 by Chunyang Zhou, Hongmei Geng, Pengfei Wang, Chunlei GuoThe predictability
of Watson–Crick base-pairing provides
a unique structural programmability to DNAs, promoting a facile design
of bimolecular reactions that perform computation. However, most of
the current architectures could only implement limited logical circuits
and are incapable of handling more complex mathematical operations,
thus limiting computing devices from advancing to the next-stage functional
complexity. Here, by designing a multifunctional DNA-based reaction
platform coupled with multiple fluorescent substrates as output reporters,
we construct, for the first time, a logic circuit that can compute
the cube root of a 10-bit binary number (within the decimal number
1000). This relatively large-scale logic system with 10 inputs and
four outputs showcases the power of DNAs in the field of biological
computing and will potentially open up a new horizon for designing
novel functional devices and complex computing circuits and bringing
breakthroughs in biocomputing.