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Temperature Dependences and Enthalpic Discrimination of Homochiral Pairwise Interactions of Six α‑Amino Acid Enantiomers in Pure Water

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journal contribution
posted on 14.05.2015, 00:00 by Jia-min Liu, Li-yuan Zhu, Hua-qin Wang, Nan Chen, Xin-gen Hu
Dilution enthalpies of six α-amino acid enantiomers (l-alanine vs d-alanine, l-serine vs d-serine, and l-proline vs d-proline) in pure water were determined at T = (288.15 to 323.15) K by isothermal titration calorimetry (ITC). Homochiral enthalpic pairwise interaction coefficients (hxx) at each temperature were evaluated according to the McMillan–Mayer theory. The hxx values of α-alanine and α-proline enantiomers are all positive (hLL > hDD > 0), while those of α-serine enantiomers are all negative (hLL < hDD < 0). In both cases, the hxx values increase uniformly and gradually with elevating temperatures. A slight but significant enthalpic discrimination effect is found in the homochiral pairwise interactions of these α-amino acid enantiomers. The positive growth of hxx values indicates that increasing temperature promotes the predominance of hydrophobic interactions in the binary aqueous solutions studied.