Synthetic Studies on Maitotoxin. 3. Stereoselective Synthesis of the BCDE-Ring System
journal contributionposted on 01.05.2008 by Masanori Satoh, Hiroyuki Koshino, Tadashi Nakata
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The stereoselective synthesis of the BCDE-ring system of maitotoxin has been accomplished through a two-directional strategy for the construction of polycyclic ether. The key reactions involve SmI2-induced double cyclization of a β-alkoxyacrylate and a double dihydroxylation for construction of the B- and E-rings.