Synthesis of Pyrido[1,2-a]indole Malonates and Amines through Aryne Annulation
journal contributionposted on 16.03.2012 by Donald C. Rogness, Nataliya A. Markina, Jesse P. Waldo, Richard C. Larock
Any type of content formally published in an academic journal, usually following a peer-review process.
Pyrido[1,2-a]indoles are known as medicinally and pharmaceutically important compounds, but there is a lack of efficient methods for their synthesis. We report a convenient and efficient route to these privileged structures starting from easily accessible 2-substituted pyridines and aryne precursors. A small library of compounds has been synthesized utilizing the developed method, affording variously substituted pyrido[1,2-a]indoles in moderate to good yields.