Synthesis of NanoQ, a Copper-Based Contrast Agent for High-Resolution Magnetic Resonance Imaging Characterization of Human Thrombus
journal contributionposted on 22.06.2011 by Dipanjan Pan, Shelton D. Caruthers, Angana Senpan, Ceren Yalaz, Allen J. Stacy, Grace Hu, Jon N. Marsh, Patrick J. Gaffney, Samuel A. Wickline, Gregory M. Lanza
Any type of content formally published in an academic journal, usually following a peer-review process.
A new site-targeted molecular imaging contrast agent based on a nanocolloidal suspension of lipid-encapsulated, organically soluble divalent copper has been developed. Concentrating a high payload of divalent copper ions per nanoparticle, this agent provides a high per-particle r1 relaxivity, allowing sensitive detection in T1-weighted magnetic resonance imaging when targeted to fibrin clots in vitro. The particle also exhibits a defined clearance and safety profile in vivo.