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Synthesis of NanoQ, a Copper-Based Contrast Agent for High-Resolution Magnetic Resonance Imaging Characterization of Human Thrombus

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posted on 22.06.2011 by Dipanjan Pan, Shelton D. Caruthers, Angana Senpan, Ceren Yalaz, Allen J. Stacy, Grace Hu, Jon N. Marsh, Patrick J. Gaffney, Samuel A. Wickline, Gregory M. Lanza
A new site-targeted molecular imaging contrast agent based on a nanocolloidal suspension of lipid-encapsulated, organically soluble divalent copper has been developed. Concentrating a high payload of divalent copper ions per nanoparticle, this agent provides a high per-particle r1 relaxivity, allowing sensitive detection in T1-weighted magnetic resonance imaging when targeted to fibrin clots in vitro. The particle also exhibits a defined clearance and safety profile in vivo.

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