Synthesis of Carbapenam Skeletons Using a Ruthenium-Catalyzed Cyclization
journal contributionposted on 13.09.2000 by Miwako Mori, Yuji Kozawa, Mayumi Nishida, Makiko Kanamaru, Kiyoko Onozuka, Masanori Takimoto
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Carbapenam is a very important skeleton of β-lactam antibiotics, and it has a highly strained structure. When enynes 9 were treated with RuH2CO(PPh3)3 (10 mol %) in toluene upon heating, carbapenams 10 were obtained in good yields.