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Synthesis of C-19-Functionalized 1α-Hydroxyvitamin D2 Analogues via Ring-Closing Metathesis

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journal contribution
posted on 01.02.2003, 00:00 by Mahmood Ahmed, Catherine E. Atkinson, Anthony G. M. Barrett, Karine Malagu, Panayiotis A. Procopiou
A heteroatom-tethered regioselective ring-closing metathesis reaction was used for the C-19 functionalization of 1α-hydroxy-5,6-trans-vitamin D2 analogues. Applications of the reaction to form a range of analogues by manipulation of the tether using both organolithium reagents and Diels−Alder cycloadditions are described.

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