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Synthesis of Aza-Fused Polycyclic Quinolines through Copper-Catalyzed Cascade Reactions

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journal contribution
posted on 02.04.2010, 00:00 by Qian Cai, Zhengqiu Li, Jiajia Wei, Liangbin Fu, Chengyong Ha, Duanqing Pei, Ke Ding
A new and efficient method for the synthesis of aza-fused polycyclic quinolines (e.g., benzimidazo[1,2-a]quinolines) is described. This protocol includes an intermolecular condensation followed by a copper-catalyzed intramolecular C−N coupling reaction. The method is applied to a wide range of 2-iodo, 2-bromo, and 2-chloro aryl aldehyde substrates to yield the aza-fused polycyclic quinolines in good yields.