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Synthesis of 4H‑1,3-Benzoxazines via Metal- and Oxidizing Reagent-Free Aromatic C–H Oxygenation

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journal contribution
posted on 20.11.2017 by Fan Xu, Xiang-Yang Qian, Yan-Jie Li, Hai-Chao Xu
An unprecedented electrochemical aromatic C–H oxygenation reaction for the synthesis of 4H-1,3-benzoxazines from easily available N-benzylamides is reported. These oxidative cyclization reactions proceed in a transition metal- and oxidizing reagent-free fashion and produce H2 as only theoretical byproduct. Adapting the C–H oxygenation reaction in an electrochemical microreactor has been demonstrated.