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Synthesis of 2-Cyclohexenone Derivatives via Gold(I)-Catalyzed Hydrative Cyclization of 1,6-Diynes

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journal contribution
posted on 03.10.2008, 00:00 by Chen Zhang, Dong-Mei Cui, Li-Ying Yao, Bi-Song Wang, Yong-Zhou Hu, Teruyuki Hayashi
The gold(I) complex (MeAuPPh3) was found to be a highly effective catalyst for the hydrative cyclization of 1,6-diynes to form the corresponding 3-methyl hex-2-enone derivatives with good to excellent yield. The proposed mechanism is described.

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