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Synthesis and Cyclodehydration of Hydroxyphenols:  A New Stereoselective Approach to 3-Aryl-2,3-dihydrobenzofurans

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journal contribution
posted on 28.09.2007 by Ferruccio Bertolini, Paolo Crotti, Valeria Di Bussolo, Franco Macchia, Mauro Pineschi
A novel and simple method for the stereoselective synthesis of substituted 3-aryl-2,3-dihydrobenzofurans by intramolecular cyclization of hydroxyphenols is described. The stereoselective ortho-C-alkylation of phenols allows a novel and stereoselective access to a diverse array of polyfunctionalized products containing a diarylmethane stereogenic center without the need for time-consuming protection−deprotection steps.

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