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Surface Re-engineering of Pancreatic Islets with Recombinant azido-Thrombomodulin

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journal contribution
posted on 21.11.2007 by Cherie L. Stabler, Xue-Long Sun, Wanxing Cui, John T. Wilson, Carolyn A. Haller, Elliot L. Chaikof
Chemoselective conjugation of an azido-functionalized thrombomodulin to pancreatic islets was achieved by Staudinger ligation to a surface-bound bifunctional poly(ethylene glycol) linker. The presence of the tethered thrombomodulin resulted in a significant increase in the production of activated protein C with a reduction in islet-mediated thrombogenicity. This report highlights the potential of tissue-targeted chemistry to reduce donor cell mediated procoagulant and proinflammatory responses.