Stereospecific Synthesis of 3,4-Dihydro‑2H‑naphtho-1,4-oxazin-2-ones by Unification of Benzoxepine-4-carboxylates with Chiral Amino Acid Ethyl Esters
journal contributionposted on 11.02.2020 by Veera Prasad Kasagani, Siva Hariprasad Kurma, China Raju Bhimapaka
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A novel and efficient stereocontrolled method has been developed for the preparation of chiral 3,4-dihydro-2H-naphtho[1,2-b][1,4]oxazin-2-ones by the reaction of benzoxepine-4-carboxylates with chiral amino acid ethyl esters for the first time. The chiral 3,4-dihydro-2H-naphtho-1,4-oxazinones have been achieved in one step by the formation of C–N, C–C, and C–O bonds.