Stereoselective Syntheses of β-l-FD4C and β-l-FddC
journal contributionposted on 30.05.1997 by Shu-Hui Chen, Xiuyan Li, Jun Li, Chuansheng Niu, Ellen Carmichael, Terrence W. Doyle
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Stereocontrolled syntheses of two potent antiviral agents, β-l-FD4C and β-l-FddC, were accomplished both in 10-step sequences, with an overall yield of 27% and 25%, respectively. It is worthwhile to mention that the introduction of a phenylseleno moiety to the C-2α position of the lactone 4 can now be performed in a stereocontrolled fashion, providing the key intermediate 5α in 75% yield.