Stereocontrolled Synthesis of Dafachronic Acid A, the Ligand for the DAF-12 Nuclear Receptor of Caenorhabditis elegans
journal contributionposted on 15.08.2007 by Simon Giroux, E. J. Corey
Any type of content formally published in an academic journal, usually following a peer-review process.
An efficient synthetic route to the DAF-12 nuclear receptor ligand of C. elegans, dafachronic acid, is described that starts with the abundant plant sterol β-stigmasterol and proceeds in 37% overall yield. The synthesis establishes the structure of this rare nematode hormone.