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Sesquiterpenes from Thapsia nitida var. meridionalis and Thapsia nitida var. nitida

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posted on 27.11.2006 by Juan J. Rubal, Francisco M. Guerra, F. Javier Moreno-Dorado, Zacarías D. Jorge, Guillermo M. Massanet, Helmer Søhoel, Ulla W. Smitt, Karla Frydenvang, S. Brøgger Christensen, Charlotte Nielsen, Margit Eriksson
Nine new eudesmanolides (19), two new guaianolides (12 and 13), and a new germacrane (10), along with a previously reported guaianolide (11), have been isolated from the roots of Thapsia nitida var. meridionalis. Thapsia nitida var. nitida also afforded compound 13 along with a new guaianolide (14). The structure of 13 was confirmed by X-ray crystallographic analysis. Compounds 1, 2, and 1114 have been tested as potential inhibitors of the sarco- and endoplasmic Ca2+-dependent ATPases (SERCA) pump. None of them showed significant activities.

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