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Sc(OTf)3‑Catalyzed Three-Component Cyclization of Arylamines, β,γ-Unsaturated α‑Ketoesters, and 1,3-Dicarbonyl Compounds for the Synthesis of Highly Substituted 1,4-Dihydropyridines and Tetrahydropyridines

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journal contribution
posted on 07.06.2013, 00:00 by Lu Liu, Ryan Sarkisian, Yongming Deng, Hong Wang
A Sc­(OTf)3-catalyzed three-component cyclization reaction of arylamines, β,γ-unsaturated α-ketoesters and 1,3-dicarbonyl compounds was developed to synthesize highly substituted 1,4-dihydropyridines and fused bicyclic tetrahydropyridines carrying a quaternary all-carbon center.

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