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Rh(III)-Catalyzed C(sp3)–H Acetoxylation of 8‑Methylquinolines

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journal contribution
posted on 06.07.2020, 21:12 by You-Ke Chen, Yan-Shang Kang, Hua-Jin Xu, Ping Zhang, Jing Zhao, Tiantian Li, Wei-Yin Sun, Yi Lu
A mild and efficient Rh­(III)-catalyzed aliphatic C–H acetoxylation directed by quinolines has been developed with widespread functional groups, including various halogens, which usually can provide precursors for further organic synthesis but easily results in selectivity issues in the Pd- and Ni-catalyzed reaction. Interestingly, Ac2O plays an essential role in promoting the transformation.