ol8b01760_si_001.pdf (5.59 MB)

Regiospecific Three-Component Aminofluorination of Olefins via Photoredox Catalysis

Download (5.59 MB)
journal contribution
posted on 18.07.2018, 13:30 by Jia-Nan Mo, Wan-Lei Yu, Jian-Qiang Chen, Xiu-Qin Hu, Peng-Fei Xu
Direct visible-light-mediated aminofluorination of styrenes has been developed with high regioselectivity. Shelf-stable N-Ts-protected 1-aminopyridine salt was used as the nitrogen-radical precursor, and the commercially available hydrogen fluoride-pyridine was used as the nucleophilic fluoride source. The synthesis of an analogue of LY503430 was performed to demonstrate the synthetic value of this strategy.