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Regiospecific Three-Component Aminofluorination of Olefins via Photoredox Catalysis

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journal contribution
posted on 18.07.2018, 13:30 by Jia-Nan Mo, Wan-Lei Yu, Jian-Qiang Chen, Xiu-Qin Hu, Peng-Fei Xu
Direct visible-light-mediated aminofluorination of styrenes has been developed with high regioselectivity. Shelf-stable N-Ts-protected 1-aminopyridine salt was used as the nitrogen-radical precursor, and the commercially available hydrogen fluoride-pyridine was used as the nucleophilic fluoride source. The synthesis of an analogue of LY503430 was performed to demonstrate the synthetic value of this strategy.

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