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Regioselective Synthesis of 2,3,4-Trisubstituted Pyrroles via Pd(II)-Catalyzed Three-Component Cascade Reactions of Amines, Alkyne Esters, and Alkenes

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journal contribution
posted on 13.09.2016 by Xu Zhang, Xuefeng Xu, Gong Chen, Wei Yi
A new, efficient, and versatile Pd­(II)-catalyzed oxidative three-component cascade reaction of diverse amines, alkyne esters, and alkenes is disclosed for the direct synthesis of diverse 2,3,4-trisubstituted pyrroles with broad functional group tolerance and in good to excellent yields. This transformation is supposed to proceed through the cascade formation of C­(sp2)–C­(sp2) and C­(sp2)–N bonds via Pd­(II)-catalyzed regioselective alkene migratory insertion, intramolecular radical addition, and oxidation sequential processes.