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Regioselective Intermolecular [2 + 2]-Cycloaddition of α‑Iodo-Unsaturated Ketones Promoted by Diisobutylaluminum Hydride

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journal contribution
posted on 29.08.2016 by Hai-Tao Zhu, Sen Ke, Ni-Ni Zhou, Ming-Jin Fan, De-Suo Yang
The development of intermolecular [2 + 2]-cycloaddition of α-iodo-unsaturated ketones in the presence of diisobutylaluminum hydride (Dibal-H) is reported to produce various trispirocyclic derivatives containing a cyclobutane ring. This sequential lactonization/[2 + 2]-cycloaddition proceeds in high regioselectivity under mild conditions.