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Regiocontrolled Synthesis of the Trimeric Quinone Framework of Conocurvone

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journal contribution
posted on 22.01.2002 by Ashkan Emadi, John S. Harwood, Sahar Kohanim, Kenneth W. Stagliano
The trimeric quinone framework of conocurvone is crucial for its potent anti-HIV activity. A new synthesis of trimeric quinones based on stepwise substitution of the halogens in 2,3-dihaloquinones by hydroxyquinone anions is described. Chlorinated biquinones are key intermediates that undergo regiospecific substitution reactions to yield trimeric quinone monomethyl ethers.

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