ol010272m_si_001.pdf (1.17 MB)

Regiocontrolled Synthesis of the Trimeric Quinone Framework of Conocurvone

Download (1.17 MB)
journal contribution
posted on 22.01.2002 by Ashkan Emadi, John S. Harwood, Sahar Kohanim, Kenneth W. Stagliano
The trimeric quinone framework of conocurvone is crucial for its potent anti-HIV activity. A new synthesis of trimeric quinones based on stepwise substitution of the halogens in 2,3-dihaloquinones by hydroxyquinone anions is described. Chlorinated biquinones are key intermediates that undergo regiospecific substitution reactions to yield trimeric quinone monomethyl ethers.