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Rearrangement Strategy for the Synthesis of 2-Aminoanilines

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journal contribution
posted on 02.04.2010 by Achim Porzelle, Michael D. Woodrow, Nicholas C. O. Tomkinson
Treatment of N-aryl hydroxylamines with trichloroacetonitrile in the presence of imidazole provides a simple and effective method for the preparation of synthetically versatile 2-aminoanilines. Reactions proceed in DMF at 40 °C, providing the products in up to 86% isolated yield.