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Proline−β3-Amino-Ester Dipeptides as Efficient Catalysts for Enantioselective Direct Aldol Reaction in Aqueous Medium

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journal contribution
posted on 18.12.2009 by Mauro De Nisco, Silvana Pedatella, Hidayat Ullah, Javid H. Zaidi, Daniele Naviglio, Özgür Özdamar, Romualdo Caputo
Dipeptides obtained from l-proline and β3-l-amino acids are reported to catalyze enantioselective direct aldol reaction in aqueous medium, leading to significant anti:syn diastereomeric ratios and enantiomeric excesses. The simple introduction of a polar substituent at the C-2 position of the β3-l-amino acid was also found to enhance appreciably both diastereo- and enantioselectivity of the catalyst.