Proline−β3-Amino-Ester Dipeptides as Efficient Catalysts for Enantioselective Direct Aldol Reaction in Aqueous Medium
journal contributionposted on 18.12.2009 by Mauro De Nisco, Silvana Pedatella, Hidayat Ullah, Javid H. Zaidi, Daniele Naviglio, Özgür Özdamar, Romualdo Caputo
Any type of content formally published in an academic journal, usually following a peer-review process.
Dipeptides obtained from l-proline and β3-l-amino acids are reported to catalyze enantioselective direct aldol reaction in aqueous medium, leading to significant anti:syn diastereomeric ratios and enantiomeric excesses. The simple introduction of a polar substituent at the C-2 position of the β3-l-amino acid was also found to enhance appreciably both diastereo- and enantioselectivity of the catalyst.