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Polymer-Bound Oxathiaphospholane:  A Solid-Phase Reagent for Regioselective Monothiophosphorylation and Monophosphorylation of Unprotected Nucleosides and Carbohydrates

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journal contribution
posted on 12.05.2005, 00:00 by Yousef Ahmadibeni, Keykavous Parang
Two polymers bound to N,N-diisopropylamino-1,3,2-oxathiaphospholane were reacted with unprotected carbohydrates and nucleosides in the presence of 1H-tetrazole, followed by oxidation with tert-butyl hydroperoxide or sulfurization with Beaucage's reagent. The 1,3,2-oxathiaphospholane ring-opening with 3-hydroxypropionitrile, followed by treatment with DBU, afforded the corresponding monophosphate and monothiophosphate derivatives, respectively, through the elimination of polymer-bound ethylene episulfide. Reactions using this strategy offer the advantages of high regioselectivity, monosubstitution, and facile isolation and recovery of products.