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Phorbasones A and B, Sesterterpenoids Isolated from the Marine Sponge Phorbas sp. and Induction of Osteoblast Differentiation

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posted on 04.03.2011 by Jung-Rae Rho, Buyng Su Hwang, Seewon Joung, Mi Ran Byun, Jeong-Ho Hong, Hee-Yoon Lee
Two new sesterterpenoids, phorbasones A (1) and B (2), were isolated from the Korean marine sponge Phorbas sp. Their complete structures were elucidated by spectral data and chemical reactions. Phorbasone A exhibited a positive effect on the calcium deposition activity in C3H10T1/2 cells. The biogenic origin of the core structure is believed to be through a novel rearrangement from the ansellone carbon structure.

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