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Phase-Vanishing Method with Acetylene Evolution and Its Utilization in Several Organic Syntheses

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journal contribution
posted on 15.05.2015 by Ryosuke Matake, Yuki Niwa, Hiroshi Matsubara
A novel quadraphasic phase-vanishing system in which acetylene is evolved from calcium carbide and directly applied in situ to the Sonogashira coupling reaction was developed. This method, which provides a safe, convenient, and one-pot means to utilize gaseous reagents without special equipment, was also applied to a Cu-catalyzed azide–alkyne cycloaddition (CuAAC) reaction and a three-component aldehyde–alkyne–amine (A3) coupling reaction with excellent results.

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