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Palladium-Catalyzed Regio- and Stereoselective Carbothiolation of Terminal Alkynes with Azolyl Sulfides

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journal contribution
posted on 21.03.2016, 00:00 by Masayuki Iwasaki, Nikola Topolovčan, Hao Hu, Yugo Nishimura, Glwadys Gagnot, Rungsaeng Na nakorn, Ramida Yuvacharaskul, Kiyohiko Nakajima, Yasushi Nishihara
Palladium-catalyzed carbothiolation of terminal alkynes with azolyl sulfides affords various 2-(azolyl)­alkenyl sulfides with perfect regio- and stereoselectivities. The present addition reaction proceeded through a direct cleavage of carbon–sulfur bonds in azolyl sulfides. The resulting adducts that are useful intermediates in organic synthesis are further transformed to multisubstituted olefins containing azolyl moieties.